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Midostaurin | 合法藥品大搜索

Midostaurin

2019年4月10日—MidostaurinisanorallyavailablesmallmoleculeinhibitorofFMS-like...arthralgia,fever,cytopenias,diarrhea,nausea,abdominalpain, ...

 Midostaurin

OVERVIEW Introduction

Midostaurin is an orally available small molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3) which is used as an antineoplastic agent in the treatment of acute myeloid leukemia with FLT3 mutations. Midostaurin is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.

Background

Midostaurin (mye" doe staw rin) is a potent small molecule multi-kinase inhibitor with specific activity against FLT3 (FMS-like tyrosine kinase 3), a tyrosine kinase receptor that is mutated in to up one-third of patients with acute myeloid leukemia (AML). The mutated FLT3 activates an intracellular signaling cascade of RAS-MEK-PI3K-AKT-STAT-5, promoting unr...

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Midostaurin | 合法藥品大搜索
AML: The most common adverse reactions were a fever in a patient with neutropenia, nausea, mucositis, vomiting, headache, petechiae, musculoskeletal pain, ... Read More
Midostaurin plus Chemotherapy for Acute Myeloid Leukemia ... | 合法藥品大搜索
2017年8月3日 — Case 21-2021: A 33-Year-Old Pregnant Woman with Fever, Abdominal Pain, and Heada... Images in Clinical Medicine Comminuted Lumbar Vertebral ... Read More
Midostaurin in Combination with Idarubicin and Cytarabine (3 ... | 合法藥品大搜索
由 J Azzi 著作 · 2018 · 被引用 2 次 — Fevers persisted despite neutrophil recovery and subsequently dissipated after completion of the final midostaurin dose. Persistent FLT3 mutation was detected ... Read More
RYDAPT (midostaurin) | 合法藥品大搜索
Hypersensitivity to midostaurin or any of the excipients (4) ... low white blood cell counts with fever (febrile neutropenia). • nausea. Read More
Side Effects of Rydapt (Midostaurin Capsules) | 合法藥品大搜索
QUESTION · low blood cell counts, fever; · bruising, nosebleeds; · high blood sugar; · infection around a needle injection; · mouth sores; · cold symptoms such as ... Read More
Patient Case Studies | 合法藥品大搜索
Do not use in patients with hypersensitivity to midostaurin or its excipients. ... Fever (101.6°F); Anemia; Upper respiratory infection; Intermittent fever ... Read More
RYDAPT® (midostaurin) capsules Side Effects | 合法藥品大搜索
What are the possible side effects of RYDAPT? · low white blood cell counts with fever (febrile neutropenia); · nausea; · redness, pain, or ulcers on the inside of ... Read More
Rydapt, INN-midostaurin | 合法藥品大搜索
2017年9月18日 — Before taking midostaurin, AML patients must have confirmation of FLT3 ... if you have fever, sore throat or mouth ulcers, because these may ... Read More
European Medicines Agency review of midostaurin (Rydapt ... | 合法藥品大搜索
由 K Tzogani 著作 · 2019 · 被引用 3 次 — European Medicines Agency review of midostaurin (Rydapt) for the treatment of ... nausea, exfoliative dermatitis, vomiting, headache, petechiae and fever. Read More
Midostaurin | 合法藥品大搜索
2019年4月10日 — Midostaurin is an orally available small molecule inhibitor of FMS-like ... arthralgia, fever, cytopenias, diarrhea, nausea, abdominal pain, ... Read More
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