Raltegravir (<i>Isentress<i>) | 合法藥品大搜索

2021年1月28日—Raltegravir(Isentress)isanHIV-1integrasestrand-transferinhibitorwithpotentantiretroviralactivity.

Raltegravir (Isentress) is an HIV-1 integrase strand-transfer inhibitor with potent antiretroviral activity. It belongs to a class of antiretrovirals called integrase inhibitors. The drug works against HIVs integrase protein, blocking its ability to integrate its genetic code into human cells.

Raltegravir (Isentress), formerly known as MK-0518, is the first licensed integrase inhibitor. It was given marketing approval in the US in 2007 and in Europe in early 2008 for use by treatment-experienced people. Raltegravir’s approval was based upon the results from the BENCHMRK 1 and 2 studies that showed it had a durable anti-HIV effect in people with limited treatment options.

The drug was approved for use in initial antiretroviral regimens by both the UK and US in 2009, based on 48-week data from the STARTMRK clinical trial. As an initial reg...