Managing Patients With Acute Pancreatitis | 合法藥品大搜索

What is the current role of somatostatin in the treatment of acute pancreatitis? What is the standard accepted line of treatment for acute pancreatitis?

Somatostatin and its long-acting analogue, octreotide, are potent inhibitors of exocrine secretion of the pancreas, which plays an important role in the pathogenesis of acute pancreatitis. In addition, somatostatin and octreotide have direct anti-inflammatory and cytoprotective effects. It has therefore been suggested that somatostatin and octreotide be used in the treatment and prevention of acute pancreatitis, and this concept has been studied extensively over the past 2 decades. The results of these trials have been mixed. While some initial smaller-scale studies showed moderate benefits, a recent multicenter randomized study involving over 300 patients revealed no benefit of octre...