The role of octreotide and somatostatin in acute and chronic ... | 合法藥品大搜索

由WUhl著作·1999·被引用104次—Treatmentofothercomplicationsofthedisease(pseudocystformation,fistulaandpancreaticascites),withsomatostatinoroctreotidehasgivenconflicting ...

Acute pancreatitis may follow a mild or a severe course. Whereas mild or edematous pancreatitis is a self-limiting disease with a low complication rate and low death rate, morbidity and mortality in severe or necrotizing pancreatitis are still unacceptably high. The major problem is the lack of a specific drug, especially in the early phase of the disease, to interfere with the systemic inflammatory response syndrome and to limit or prevent complications of the disease. Although the initiating pathophysiological process is not known, the destruction of the gland (autodigestion) by digestive enzymes may be responsible for disease progression. Inhibition of pancreatic activity, which reduces exocrine secretion and further prevents the release and activation of enzymes, was therefore suggested as a specific treatment concept. The results of clinical investigations using somatostatin or its analogue are controversial, s...