Loading dose required to achieve rapid therapeutic ... | 合法藥品大搜索

由JTWang著作·2012·被引用18次—Maintenancedosesof6mg/kgwereadministeredeveryday,everyotherdayoreverythirddaydependingontheindividual'screatinineclearance,andteicoplanin ...

Teicoplanin is an antibiotic drug prescribed for the treatment of multidrug-resistant Gram-positive infections. However, there is currently no consensus as to the optimal teicoplanin loading dose. The objective of this study was to compare plasma concentrations of teicoplanin in patients with multidrug-resistant Gram-positive infections after the administration of two different loading doses. Two groups of patients were infused intravenously with four loading doses of 6 mg/kg body-weight (group A, n = 12) or 12 mg/kg body-weight (group B, n = 11). The first three loading doses were administered at 12-hr intervals, and the fourth was given 24 hr after the third dose. Maintenance doses of 6 mg/kg were administered every day, every other day or every third day depending on the individuals creatinine clearance, and teicoplanin trough plasma concentrations were monitored. Only samples obtained on the same day for both gr...