Loading Dose | 合法藥品大搜索

由AMiniaci著作·2020—Definition/Introduction·LD=(VolumeofDistributionXConcentrationSteadyState)/Bioavailability·Vd=Doseofmedicationgiven/Concentrationin ...

Loading doses are a means to quicks achieve therapeutic drug concentrations or prompt an immediate clinical response. Loading doses are larger than maintenance doses and are usually administered as a single bolus, although some drugs (eg, amiodarone or digoxin) may require multiple loading doses administered over several hours to days.[1] An intravenous loading dose of phenytoin, on the other hand, should be administered as a single dose. Medications with shorter half-lives (eg, heparin for treating pulmonary embolism) may also require a loading dose to achieve their therapeutic effect immediately.

In medicine, the treatment for most conditions uses various pharmacological medications. For each of these individual medications, the route of administration, appropriate dosage, and frequency of use are determined by the medication’s ...