抗凝血劑過量中毒治療@ 急診小醫師 | 合法藥品大搜索

2018-09-23

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906185/[1]

idarucizumab 是 Dabigatran  解毒劑. 

凝血酶複合濃縮物 (prothrombin complex concentrate; PCC) intermediate purity pooled plasma products containing a mixture of vitamin K-dependent proteins

PCCs — Prothrombin complex concentrates (PCCs) contain vitamin K-dependent clotting factors that co-purify together. The 4-factor PCCs contain the procoagulant factors II, VII, IX, and X (as well as the anticoagulant proteins S and C) and thus supply all of the vitamin K-dependent procoagulant factors. The 3-factor PCCs contain factors II, IX, and X (and proteins S and C) but only small amounts of factor VII. Activated PCCs (aPCCs; eg, factor eight inhibitor bypassing activity [FEIBA]) contain factor VII in the activated form (factor VIIa); the other factors are the same as in 4-factor PCCs.

Available PCC products are summarized in the table (table 2). Clinical use is discussed in detail in UpToDate drug i...