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由BJSteinhoff著作·2019·被引用17次—Levetiracetam(LEV)andbrivaracetam(BRV)arepyrrolidonederivatecompoundsbindingatthepresynapticSV2Areceptorsiteandarethus ...

Ther Adv Neurol Disord. 2019; 12: 1756286419873518.

Kork Epilepsy Center, Landstr. 1, 77694 Kehl-Kork, Germany

Epilepsiezentrum Kork, Kehl-Kork, Germany

Bernhard J. Steinhoff, Kork Epilepsy Center, Landstr. 1, 77694 Kehl-Kork, Germany;

Received 2019 Jun 27; Accepted 2019 Aug 12.

Until the early 1990s, a limited number of antiepileptic drugs (AEDs) were available. Since then, a large variety of new AEDs have been developed and introduced, several of them offering new modes of action. One of these new AED families is described and reviewed in this article. Levetiracetam (LEV) and brivaracetam (BRV) are pyrrolidone derivate compounds binding at the presynaptic SV2A receptor site and are thus representative of AEDs with a unique mode of action. LEV was extensively investigated in randomized controlled trials and has a very pr...