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Danazol increases T regulatory cells in patients with ... | 合法藥品大搜索

Danazol increases T regulatory cells in patients with ...

由HKhurana著作·2018·被引用4次—Objectives:Danazolisanattenuatedandrogenandisusedinthetreatmentofaplasticanemia(AA)inresourceconstraintsettings.Wechosetostudytheroleof​ ...

 Danazol increases T regulatory cells in patients with ...

Objectives: Danazol is an attenuated androgen and is used in the treatment of aplastic anemia (AA) in resource constraint settings. We chose to study the role of CD4+ CD25high CD127low FoxP3+ T regulatory cells (T-regs) in the pathophysiology of AA and their response to treatment with Danazol alone or in combination with immunosuppressive treatment (IST).

Methods: T-regs percentages of 25 acquired idiopathic AA patients and 25 healthy controls who completed study protocol were analyzed by performing multicolor flowcytometry on peripheral blood samples.

Results: More than one-third (36%) of AA patients in our study received Danazol as monotherapy, whereas less than a third (32%) each received standard doses of IST with equine Anti Thymocyte Globulin (ATG) and Cyclosporine combination, or Cyclosporine and Danazol combination, respectively. Results showed that all AA patients had a sig...

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Danazol as first | 合法藥品大搜索
由 JC Jaime-Pérez 著作 · 2011 · 被引用 65 次 — No patient treated with danazol suffered clonal evolution of his/her disease. Although ATG plus CsA is the therapy of choice for AA patients ... Read More
Danazol increases T regulatory cells in patients with ... | 合法藥品大搜索
由 H Khurana 著作 · 2018 · 被引用 4 次 — Objectives: Danazol is an attenuated androgen and is used in the treatment of aplastic anemia (AA) in resource constraint settings. We chose to study the role of​ ... Read More
Danazol therapy for aplastic anemia refractory to ... | 合法藥品大搜索
由 T Chuhjo 著作 · 2008 · 被引用 39 次 — Sixteen patients (12 males and four females; six severe cases and 10 moderate cases) were treated with 300 mg of danazol daily for 12 weeks. All patients ... Read More
[Severe aplastic anemia remarkably improved by a treatment ... | 合法藥品大搜索
由 K Miyamura 著作 · 1989 — Treatment schedule were 1) m-PSL 1,000 mg (day 1-4), 500 mg (5-8)--then tapered. 2) ALG lg/day (day 4-8) 3) danazol 600 mg/day. During ALG administration, ... Read More
Danazol increases T regulatory cells in patients with aplastic ... | 合法藥品大搜索
由 H Khurana 著作 · 2018 · 被引用 4 次 — Objectives: Danazol is an attenuated androgen and is used in the treatment of aplastic anemia (AA) in resource constraint settings. We chose to ... Read More
Danazol for Genetic Bone Marrow and Lung Disorders | 合法藥品大搜索
Currently, doctors use a male hormone-based drug called Danazol to improve bone marrow function and treat aplastic anemia. More information is needed on ... Read More
Nontransplant therapy for bone marrow failure | 合法藥品大搜索
2016年12月2日 — Danazol, which is traditionally less preferred for treating cytopenias, ... During the last 3 decades, patients with aplastic anemia (AA) have ... Read More
Danazol therapy for aplastic anemia refractory to ... | 合法藥品大搜索
由 T Chuhjo 著作 · 2008 · 被引用 39 次 — Although there are anecdotal reports of the efficacy of danazol in the treatment of aplastic anemia (AA), there has been no systematic study to ... Read More
(PDF) Danazol as first | 合法藥品大搜索
The beneficial effect of danazol has also been shown in treating aplastic anemia and myelodysplastic syndromes (MDS), characterized by ineffective ... Read More
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