Nontransplant therapy for bone marrow failure | 合法藥品大搜索

2016年12月2日—Danazol,whichistraditionallylesspreferredfortreatingcytopenias,...Duringthelast3decades,patientswithaplasticanemia(AA)have ...

Although the exact pathophysiology for most AA cases is still unclear, evidence deduced from clinical and laboratory studies clearly implicates a progressive immune-mediated destruction of the bone marrow compartment, and in particular of the hematopoietic stem and progenitor cells (HSPC) as the principle mechanism responsible for AA-associated cytopenias.2  The severely reduced HSPC pool may explain persistent pancytopenia in some patients, despite repeated IST. Thus, pharmacological stimulation of HSPC self-renewal and proliferation could be a rational approach for these patients with otherwise limited therapeutic options. However, the addition of hematopoietic growth factors such as granulocyte colony-stimulating factor or erythropoietin have not resulted in higher response rates compared with IST alone in previous studies.3-5[1] 

In 2008, the thrombopoietin (TPO) receptor agonist eltromb...