Hydralazine | 合法藥品大搜索

Pharm.Class.vasodilators.Indications.Moderatetoseverehypertension(withadiuretic).UnlabeledUse(s):.HFunresponsivetoconventionaltherapywith ...

General

Genetic Implications:

Pronunciation: hye-dral-a-zeen

Trade Name(s)

Ther. Class.

antihypertensives[3]

Pharm. Class.

vasodilators

Indications

Moderate to severe hypertension.

Unlabeled Use(s):

New York Heart Associated Class III or IV HF with reduced ejection fraction (in combination with isosorbide dinitrate).

Action

Direct-acting peripheral arteriolar vasodilator.

Therapeutic Effect(s):

Lowering of BP in hypertensive patients and decreased afterload in patients with HF.

Pharmacokinetics

Absorption: Rapidly absorbed following oral administration; well absorbed from IM sites. IV administration results in complete bioavailability.

Distribution: Widely distributed.

Metabolism and Excretion: Mostly metabolized by the GI mucosa and liver by N-acetyltransferase  (rate of acetyl...