What is integrin? | 合法藥品大搜索

Integrinsareproteinsthatfunctionmechanically,byattachingthecellcytoskeletontotheextracellularmatrix(ECM),andbiochemically,bysensingwhether ...

Integrins[1] are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers. Integrins function as adhesion receptors for extracellular ligands and transduce biochemical signals into the cell, through downstream effector proteins. Remarkably, they function bidirectionally, meaning they can transmit information both outside-in and inside-out (reviewed in [1][2]).

Integrin α subunit domains: Top: Linear domain arrangement. Middle: The globular structure formed by protein domains. Bottom: simplified version of the integrin α subunit. The αI domain is present in some subtypes of the α subunit.

Each integrin heterodimer consist...