Integrins | 合法藥品大搜索

由BAlberts著作·2002·被引用169次—Integrinsaretheprincipalreceptorsusedbyanimalcellstobindtotheextracellularmatrix.Theyareheterodimersandfunctionastransmembranelinkersbetween ...

The linkage[1] of the extracellular matrix[2] to the cell requires transmembrane cell adhesion proteins that act as matrix receptors and tie the matrix to the cells cytoskeleton[3]. Although we have seen that some transmembrane proteoglycans function as co-receptors for matrix components, the principal receptors on animal cells for binding most extracellular matrix proteins—including collagens, fibronectin[4], and laminins—are the integrins[5]. These constitute a large family of homologous[6] transmembrane, cell-matrix adhesion receptors. In blood cells, as we have seen, integrins also serve as cell-cell adhesion molecules, helping the cells bind to other cells, as well as to the extracellular matrix.

Integrins, like other cell adhesion molecules, differ from cell-surface receptors for hormones and for other extracellular soluble signal molecules in that they usually bind their ligand[7] with lower affinity and are usually present at about tenfold to a hundredfold higher conce...