How is integrin activated? | 合法藥品大搜索
Integrinactivationisanimportantmechanismthroughwhichcellsregulateintegrinfunctionbymanipulatingtheligandaffinityofintegrinsspatiallyandtemporally.
Integrin[1] activation is an important mechanism through which cells regulate integrin function by manipulating the ligand affinity of integrins spatially and temporally. Structural and functional studies suggest that integrins can exist in different ligand affinity states – low, intermediate and high (reviewed in [1]). Crystal structures have revealed that integrin heterodimers, occur in an inactive, bent V-shape with the head close to the membrane-proximal regions of the legs [2][3], maintained by the α/β salt bridge at the inner membrane region and helix packing of the transmembrane (TM) region [4]. This low affinity structure undergoes rapid, reversible conformational changes to increase ligand affinity, termed “activation” (reviewed in [5][6][7]).
The Structural hallmarks of integrin activation are:
a) complete extension of the extracellular domains and
b) separation of the cytoplasmic leg domains (structural rear...
整合素 | 合法藥品大搜索
Integrin | 合法藥品大搜索
What is integrin? | 合法藥品大搜索
How is integrin activated? | 合法藥品大搜索
Integrins | 合法藥品大搜索
Integrins | 合法藥品大搜索
Integrins | 合法藥品大搜索
Integrin Cell Signaling Pathway | 合法藥品大搜索
Integrin | 合法藥品大搜索
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