Integrin Cell Signaling Pathway | 合法藥品大搜索

Interactionsbetweenintegrinsandtheextracellularmatrixmediateintracellularsignalingmechanismstoregulatecellsurvival,differentiation,cellcycle ...

Integrins are cell surface receptors that interact with the extracellular matrix. They mediate intracellular signals in response to the extracellular matrix including cellular shape, mobility, and progression through the cell cycle [1].  The integrin family of proteins is the major cell surface receptors involved in mediating cellular response to ECM binding. Composed of alpha and beta subunits, integrin receptors form structural and functional linkages between the ECM and intracellular cytoskeletal linker proteins [2]. Signaling mediated from intergrin/ECM interactions are also integrated with cellular responses to growth factor signaling to regulate cellular proliferation, cytoskeletal reorganization and other responses necessary for cellular survival. Thermo Scientific™ has a wide range of products to help with integrin research. 

While not possessing kinase domains, integrin receptors can activate a number of intracellular signaling pathways and targets following ECM adhes...